|The Health of Wealth
Patients taking blood thinners raise dental treatment concerns
Medications preventing the formation of blood clots are commonly called blood thinners. Blood thinners do not actually thin the blood, but they prevent the blood from clotting. These types of medications are given to people with an increased tendency for thrombosis (blood clot formation) inside blood vessels or to prevent the formation of further clots in those who have had them before.
Blood clots that break free can travel through the bloodstream and then lodge in a vessel blocking blood flow. When a blockage occurs in a vessel to the brain, a stroke occurs. Blockage to the heart causes a heart attack. Blood thinners help prevent the serious risk of heart attack and stroke internal clotting poses.
Aspirin is commonly used to relieve mild to moderate pain, such as pain associated with headache and menstrual cramps. Aspirin is often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication to reduce swelling. It is also used in combination with other pain relievers for migraine headaches and prescription medications for relief of moderate to severe pain.
Since the 1980s, aspirin has been used as a preventive treatment for heart attacks and strokes. Aspirin has an anti-clotting effect and is used in long-term, low doses to prevent heart attacks, strokes and blood clot formation in people at high risk for developing blood clots. The usual dose is one baby aspirin, 81 mg, taken once a day.
Low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or the death of cardiac tissue. For emergency treatment, one full strength aspirin (325 mg) is given during or immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue. Higher doses are also used after placement of coronary stents and following some cardiac procedures.
(Vitamin K antagonists)
Coumarines are a class of anticlotting pharmaceuticals prescribed for more than 1 million Americans each year. Coumarines act by blocking the action of the Vitamin K necessary for the production of prothrombin, which is needed for blood clotting. It takes at least 48 to 72 hours for the anticlotting effect to develop fully. The most common coumarine medication used is warfarin (also known under the brand names Coumadin, Jantoven, Marevan, and Waran). Generally, warfarin and other coumarin drugs are used to treat patients with atrial fibrillation (the heart’s two upper chambers fibrillate or beat out of normal rhythm), deep venous thrombosis (clotting in the deep leg veins) and pulmonary embolism (blood clots moving into the lungs). Warfarin is also routinely given to patients who have artificial heart valves.
Warfarin can cause serious bleeding. To avoid this, people who take this medication must have routine blood testing to monitor their INR (International Normalized Ratio). This is an international measure of clotting, which attributes a value of 1.0 to people with a normal ability to clot. As the INR increases, it reflects a person is less likely to form blood clots. Patients with atrial fibrillation must maintain an INR of 2-3 in order to effectively decrease their risk of stroke.
Heparin acts by inactivating thrombin and several other clotting factors required for a clot to form. Heparin is used in the hospital intravenously in order to prevent blood clot formation and to enhance the body’s ability to break down existing blood clots. Heparin works immediately at the site used to prevent clotting.
Dental treatment for patients on thinners
Blood thinners do not affect most dental procedures. However, blood thinners can have an effect on blood clotting during dental surgery. Depending on the medication, the dosage and the extent of dental surgery, bleeding can be a concern. The low level of aspirin use for blood thinning is rarely a concern. However, stopping aspirin use the day before dental surgery is usually recommended.
Warfarin use presents the most common potential bleeding problems dentists encounter. Stopping coumarin medication prior to dental treatment is controversial. Because it takes 48 to 72 hours for warfarin to be effective, it must be stopped two or three days before treatment, which puts the patient at risk for serious blood clotting complications. So the risk-benefit has to be determined, that is, uncontrolled bleeding verses blood clot formation in the vessels.
Warfarin should not be stopped for most dental procedures, including most extractions and implant placements. But with any dental surgery, a consultation with the patient’s physician and a recent INR blood test should be reviewed. Usually, an INR up to 2.5 is acceptable and safe for dental surgery, thus coumarin does not need to be stopped or lowered. With a common sense approach, I ask my patients if they clot, that is, the bleeding stops, in a reasonable amount of time with direct pressure on a skin cut. During dental surgery, treatment can be done to enhance clotting, such as the use of clotting agents, stitches, bone grafts and membranes. Bone grafts and membranes preserve bone in an extraction site as well as reduce bleeding.
Last year, I saw a dental phobic 57-year-old patient, Todd, who was taking warfarin for deep venous thrombosis from poor circulation in his lower legs and thighs. He was in severe pain from a split lower left molar and needed an extraction. After consulting with his physician and determining his INR was 2.2, Todd continued his normal warfarin regime. With conscious sedation, his tooth was removed and a bone graft and membrane were placed with no bleeding complications. He was comfortable throughout the procedure with no memory of the event.
Eight weeks later, a root replacement titanium implant was placed under conscious sedation, with him continuing his warfarin use.
Just as during his first treatment, Todd had no bleeding problems and happily had no memory of the implant procedure. Four months later, an implant crown was fabricated and placed with the same great results."
While a risk-benefit assessment, bleeding verses clotting, must be made for each patient, dentists can perform most dental treatments safely for patients taking warfarin without the need for stopping warfarin therapy.
Enjoy life and keep smiling.
George Malkemus has had a Family and Cosmetic Dental Practice in Rohnert Park for over 27 years at 2 Padre Parkway, Suite 200. Call 585-8595, or email info@ malkemusdds.com. Visit Dr. Malkemus’ Web site at http://www.malkemusdds.com.